Test_pellets
Pellets – an oral dosage form to improve patient compliance
Our Vismon® coating technology stimulates salivation and creates a pleasant tasting, soft pellet pulp in the mouth that is easy to swallow.
Pellets are small, rounded, spherical nuclei with an average diameter of 0.1 to 3 mm. The surface of pellets is typically smooth and not very porous.
Pellets can be formulated as immediate release or sustained release dosage forms and can also be coated to deliver drugs to specific sites in the gastrointestinal tract. Due to their free-flowing properties, pellets offer a high degree of flexibility in formulation development.
Pelletisation can be achieved by layering the drug onto the starter pellet or by ring die extrusion and spheronisation:
Drug layering
Drug layering is similar to a film coating process. One or more active ingredients are applied in layers as a solution or suspension onto starter pellets (e.g. sugar starch, MCC or tartaric acid spheres with a size range of 0.1 to 2 mm).
Extruded pellets
Extruded pellets are produced by a granulation process in which a powder mixture of API and excipients is agglomerated using a binding liquid. The material is then processed in a ring die extruder to produce high density extrudates. These extrudates are then formed into small rounded or spherical pellets.
Recent Project at Losan: Dual Release Pellets
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Pharmaceutical pellets services
Pellets by extrusion/spheronisation or using starter pellets
Transfer trials
Scale-up from pilot to commercial scale
GMP manufacturing: Production of clinical trial supplies, release of study medication (?) and stability studies
Extensive dosage form capabilities:
- Customised release by fluid bed coating (targeted release, extended release)
- Matrix formulations by double chamber filling of immediate and extended release pellets
- Capsules and stick packs
Advantages of our Pellets
The main advantages for the development and use of pharmaceutical pellets are:
Preparation of modified release multiple dosage forms with different drug release patterns
Taste masking of bitter tasting drugs
Easy to swallow thanks to our Vismon® coating technology
Polymer-based pellets for controlled drug release patterns
Increased mechanical strength of the dosage form
Flexibility in dosage form design and development
Can be used to combine incompatible drugs
Avoid high local concentrations as they disperse freely in the GI tract
Minimise potential side effects without decreasing bioavailability
Compared to monolithic forms, multiparticulate distribution of particles in the GI tract reduces fluctuations in plasma levels
Losan Pharma technologies: hot melt extrusion | hot melt coating | nanotechnology | mesoporous silica | stick packs | spray drying | coatings | matrix tablets | ODTs